Do BMMFs, the novel infectious agents found in dairy products and bovine sera, play a role in the development of colorectal cancer? Scientists led by Harald zur Hausen detected the pathogens in colorectal cancer patients in close proximity to tumors. The researchers show that the BMMFs trigger local chronic inflammation, which can cause mutations via activated oxygen molecules and thus promote cancer development in the long term.

Women have an increased risk of breast cancer if they have a family history of this disease. However, the risk may also be higher if first-degree family members have another type of cancer, according to a study by a team of scientists and physicians from the National Center for Tumor Diseases (NCT) Heidelberg, the German Cancer Research Center (DKFZ) and Heidelberg University Hospital (UKHD), as well as international colleagues.

Article - 10/03/2021

Faster to single cells using miniature grinder

Tissue cells are needed for medical diagnostics, cell therapies and tissue engineering, among other things. A novel tissue grinder gently and automatically dissociates cells from tissue. In November 2020, the newly founded biotech company Fast Forward Discoveries GmbH (FFX) delivered its first tissue grinders to customers.

Paper technology - 10/03/2021

PLAFCO – a sustainable plastic substitute made from paper

Plastic is indispensable: it is cheap and practical and found in many disposable products such as drinking straws, disposable tableware or even packaging like bonded beverage cartons or bags – and it has a disastrous effect on the environment. The start-up company Plafco Fibertech Oy has developed a sustainable plastic substitute made of paper that could replace many disposable plastic products in the future.

CureVac N.V. (Nasdaq: CVAC), a global biopharmaceutical company developing a new class of transformative medicines based on messenger ribonucleic acid (mRNA), and Novartis AG announced today that they have signed an initial agreement for the manufacturing of CureVac’s COVID-19 vaccine candidate, CVnCoV. Preparations for the start of production, technology transfers and test runs are already underway.

Induced pluripotent stem cells (iPSC) are suitable for discovering the genes that underly complex and also rare genetic diseases. Scientists from the German Cancer Research Center (DKFZ) and the European Molecular Biology Laboratory (EMBL), together with international partners, have studied genotype-phenotype relationships in iPSCs using data from approximately one thousand donors.

A new network has been set up in Baden-Württemberg aimed at reducing animal experiments as well as further improving animal welfare. It combines new approaches and measures at the state’s biomedical research locations, which are expected to limit stress in laboratory animals and steadily reduce the number of animals used in research in line with the 3R principles of Replacement, Reduction, and Refinement.

Expert interview - 03/03/2021

Healthcare movers – the future of Baden-Württemberg's healthcare industry

The 'Healthcare Movers 2020 - Baden-Württemberg Report' reveals the potentials and challenges Baden-Württemberg healthcare companies encounter as the digital transformation of the healthcare market progresses. In an interview with Dr. Ariane Pott from BIOPRO, the authors of the report, Beatus Hofrichter and Dr. Ursula Kramer, explain what is required to take the major step towards becoming a digital avant-garde company.

On 8 February, the European Parliament adopted its Own Initiative Report on the Circular Economy which recognised the role of bioplastics for the future. Amongst other issues highlighted, the MEPs emphasised the potential role of bio–based and biodegradable and compostable plastics in the circular economy whilst noting that bio-based and/or biodegradable plastics alone will not provide a solution to the environmental concerns related to plastics.

So-called silent mutations have no effect on the composition of a protein. They are therefore not considered to promote cancer. However, scientists from the German Consortium for Translational Cancer Research (DKTK), partner site Essen, now describe in a case of kidney cancer an overlooked silent mutation with a major impact on prognosis.

Neuroblastoma can spread relentlessly or shrink spontaneously. Scientists from the Hopp Children’s Cancer Center Heidelberg (KiTZ), the German Cancer Research Center (DKFZ), the University of Heidelberg and the National Center for Tumor Diseases (NCT) Heidelberg have shown that some malignant neuroblastomas employ a trick to avoid cell death: they use a special mechanism to lengthen the telomeres at the end of their chromosomes.

The European Commission agreed on the successor of BBI JU – the Circular Bio-based Europe Joint Undertaking (CBE JU) in a legislative proposal adopted today. The new partnership between the EU and the Bio-based Industries Consortium (BIC) is expected to build on the success of BBI JU while stepping up its contribution to the EU’s climate targets, in line with the European Green Deal. The European Parliament and Council will now study the…

Agrivoltaics enables the dual use of arable land: Photovoltaic modules, which are mounted on a structure, generate renewable electricity and underneath agricultural crops grow. The approach increases land efficiency and could mitigate conflicts over the use of arable land in the future. A new guideline provides up-to-date information on the technology, its potential and the current state of development.

Researchers from EMBL and Heidelberg University Hospital combine high-resolution imaging to observe the infection process in cell nuclei, opening the door for new therapeutics.

Article - 17/02/2021

Whole blood model enables development of early warning system for sepsis

Sepsis is a life-threatening disease that can be treated all the more successfully the faster therapy is initiated. It is not just the infection itself that is so dangerous, but a dysregulated response of the immune system. Physicians at Ulm University Hospital have now developed an animal-free test system that can be used to research the disease and develop innovative diagnostic tools to quickly assess a patient's sepsis risk and optimise…

An international research team involving the universities of Paraná and Tübingen has developed a rapid test that can reliably identify Covid-19 antibodies in the blood within minutes. As the researchers report in the journal ACS Sensors, the new process is based on a simple measuring principle making it easy to carry out without expensive instruments, and is therefore suitable for use at mobile testing centers or by laboratories.

Textiles can be coated with the biopolymer chitosan and thus made water-repellent by binding hydrophobic molecules. The good thing is that this can also replace toxic and petroleum-based substances that are currently used for textile finishing. In the last few years Fraunhofer IGB and partners have developed technology to provide fibers with the desired properties using biotechnological processes and chitosan.

University of Hohenheim project contributes to maintaining valuable biotopes: Autonomous robot to help prune fruit trees so they stay healthy.

From field to socket - 03/02/2021

Energy park & Donau-Silphie: a symbiosis that benefits nature

Biogas plants that produce non-fossil fuels are very much in vogue at the moment. In the Swabian hamlet of Hahnennest, four family farms have joined forces to form an energy park and operate a local biogas plant, covering everything from substrate production to the sale of energy.

Microbiologists at the University of Tübingen modify bacteria to produce climate-neutral and rapidly degradable bioplastics.